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KMID : 0043319860090030183
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Archives of Pharmacal Research
1986 Volume.9 No. 3 p.183 ~ p.187
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Effects of Some Organophosphate Pesticides on the Murine Immune System following Subchronic Exposure (II)
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Moon CK
Yun YP/Lee SH
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Abstract
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Some of organophosphate pesticides which are the most heavily used in Korea, were examined for their effects on the murine immune system. Immunotoxicological assay parameters adopted in this study were Arthus reaction for humoral immunity, delayed type hypersensitivity reaction for cell mediated immunity, carbon clearance for macrophage function and susceptibility to tumor challenge. Subchronic exposure of rodents to the pesticides resulted in the marked suppression of immune functions and enhancement of susceptibility to tumor challenge. Among the pesticides tested (fenitrothion, fenthion, diazinon and EPN), fenitrothion was the most suppressive in Arthus and delayed type hypersensitivity reaction.
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